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Kale, M. K.
- Antiparkinsonian Effect of Cassia tora on Oxotremorine Induced Parkinson Methodology
Abstract Views :369 |
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Authors
C. P. Suryawanshi
1,
V. R. Patil
1,
R. Y. Chaudhari
1,
M. K. Kale
2,
S. D. Firake
2,
R. B. Pimprikar
3,
M. D. Patil
3,
S. B. Yeshwante
3,
D. S. Saindanem
3
Affiliations
1 Tapi Valley Education Society's Hon.L.M.C. College of Pharmacy, Faizpur Dist. Jalgaon (MS), IN
2 K.Y.D.S.C.T's College of Pharmacy, Sakegaon, Tal-Bhusawal, Dist. Jalgaon 425201, IN
3 Nagaon Education Society's Gangamai College of Pharmacy, Nagaon.424005 Dist Dhule (MS), IN
1 Tapi Valley Education Society's Hon.L.M.C. College of Pharmacy, Faizpur Dist. Jalgaon (MS), IN
2 K.Y.D.S.C.T's College of Pharmacy, Sakegaon, Tal-Bhusawal, Dist. Jalgaon 425201, IN
3 Nagaon Education Society's Gangamai College of Pharmacy, Nagaon.424005 Dist Dhule (MS), IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 1, No 1 (2009), Pagination: 35-38Abstract
The Parkinson's disease is mainly distinguished from other diseases based on the key feature that is tremors. Oxotremorine induced oxidative stress is implicated as a common pathway in development of Parkinson's symptoms like, tremor, salivation and temperature variation. Hence Oxotremorine-induced tremor model was used to evaluate antiparkinsonian drugs. Different extracts of plant of Cassia tora such as, petroleum ether (200mg/kg) p.o., methanolic (200mg/kg) p.o. and ethyl acetate extract (200mg/Kg) p.o. were used to investigate antiparkinsonian effect on oxotremorine induced Parkinson's symptoms in mice. Procyclidine, an anticholinergic, antiparkinsonian drug was administered as a standard drug at a dose of 5mg/kg p.o., 1hr prior the administration of oxotremorine (0.5mg/kg) S.C. Methanolic extract at 200mg/kg p.o route of administration decreased (p<0.05) Parkinson's symptoms, while petroleum ether extract (200mg/kg)p.o and ethyl acetate extract (200mg/kg)p.o shows moderate action. This study suggests that cassia tora is a plant with possible therapeutic value for Parkinson's disease.Keywords
Parkinson's Disease, Oxotremorine, Tremor, Procyclidine.
References
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- Haematological Evaluation of Moringa pterygosperma Gaertn. Leaves Extract in Phenylhydrazine Induced Anaemia in Rats
Abstract Views :282 |
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Authors
Affiliations
1 KYDSCT'S College of Pharmacy, Sakegaon, Tal. - Bhusawal, Dist. - Jalgaon 425 201(M.S.), IN
2 Institute of Pharmaceutical Education & Research, Borgaon (Meghe), Wardha - 442 001, IN
1 KYDSCT'S College of Pharmacy, Sakegaon, Tal. - Bhusawal, Dist. - Jalgaon 425 201(M.S.), IN
2 Institute of Pharmaceutical Education & Research, Borgaon (Meghe), Wardha - 442 001, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 2, No 6 (2010), Pagination: 392-396Abstract
The extracts of Moringa pterygosperma were tested against Phenylhydrazine induced anaemia in rats and the changes in different haematological parameters have been evaluated. It has been found that the extract of Moringa pterygosperma produces significant increase in haematological parameters particularly Hb content, RBC counts, Haematocrit, Plateletcrit etc.Keywords
Moringa pterygosperma Gaertn, Phenylhydrazine (PHZ), Red Blood Cell (RBC) Count, Haemoglobin (Hb).References
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- Anti-Diarrheal Activity of Methanolic and Aqueous Extracts of Dillenia indica L
Abstract Views :212 |
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Authors
S. B. Yeshwante
1,
A. R. Juvekar
1,
R. B. Pimprikar
2,
R. T. Kakade
2,
M. Tabrej
2,
M. K. Kale
3,
S. D. Firke
3
Affiliations
1 Department of Pharmacology, Institute of Chemical Technology, Matunga, Mumbai- 400019, IN
2 Gangamai College of Pharmacy, Nagaon, Dhule, IN
3 KYDSCT's College of Pharmacy, Sakegaon, Jalgaon, IN
1 Department of Pharmacology, Institute of Chemical Technology, Matunga, Mumbai- 400019, IN
2 Gangamai College of Pharmacy, Nagaon, Dhule, IN
3 KYDSCT's College of Pharmacy, Sakegaon, Jalgaon, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 1, No 3 (2009), Pagination: 140-142Abstract
The methanolic extract of Dillenia indica leaves have been reported to possess anti-inflammatory activity. Inflammatory mediators such as prostaglandins and bradykinins are involved in the pathogenesis of diarrhea. The aim of the present work was to evaluate the anti-diarrheal activity of aqueous and methanolic extracts of Dillenia indica leaves. The anti-diarrheal activity was evaluated using Castor oil induced diarrhea model and different parameters such as onset of diarrhea and total number of feaces for the period of 4 hours. were observed. The results of test group were compared with Vehicle control group using one way ANOVA followed by Dunnett's Test. The results revelaled that both extracts at doses of 200 and 400mg/kg P.O. showed significant (P<0.01) prolongation of onset of diarrhea and significant (P<0.01) reduction in total number of feaces after 2nd hour of treatment while dose of 100mg does not show any activity. From the results it can be concluded that the inhibition of the diarrhea and prolongation of onset might be due to inhibition of inflammatory mediator release and phyto-constituents such as flavonoids and tannins may have also contributed to the anti-diarrheal activity.Keywords
Dillenia indica, Dilleniaceae, Castor Oil, Aqueous and Methanolic Extracts.References
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